Protection of deliquescence of sodium valproate from humidity was accomplished successfully by a solid-solid reaction with hydrotalcite. The level of protection was comparable to that obtained when the compound is synthesized by ion-exchange reaction in aqueous solution. The merit of the solid-solid reaction is enormous because the procedure consists of simply grinding the solid sodium valproate with hydrotalcite for 5 min.
Hirokazu Nakayama and Aki Hayashi
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