Protection of Deliquescence of Sodium Valproate by Hydrotalcite Using Different Synthetic Routes

Protection of deliquescence of sodium valproate from humidity was accomplished successfully by a solid-solid reaction with hydrotalcite. The level of protection was comparable to that obtained when the compound is synthesized by ion-exchange reaction in aqueous solution. The merit of the solid-solid reaction is enormous because the procedure consists of simply grinding the solid sodium valproate with hydrotalcite for 5 min.

Hirokazu Nakayama and Aki Hayashi