Abstract

Targeting Approaches for Effective Therapeutics of Bone Tuberculosis

Bone and Joint Tuberculosis (TB) is the major and commonly occurring type of extra pulmonary mycobacterial disease. Since last twenty years the occurrence of bone TB has augmented marginally in specifically economically backward or developing nations due to malnutrition. Moreover decrease in immunity results in increase in occurrence in patients suffering from AIDS. Bone TB is also found in cases where the organism has developed resistance to the drug treatment of pulmonary TB and when there is propagation of tuberculosis from the affected lungs to the whole body through the blood vessels. Corrective Surgery along with precise antitubercular drug therapy for longer period of time is commonly preferred in subjects where neurological defects are occurring along with bone deformity. This combined treatment has exhibited satisfactory results. The present line of treatment for bone TB includes ATDs administered by oral/ intravenous or intramuscular route coupled along with surgical treatment of incorporating Autogenous bone graft and Titanium Mesh Cage to regenerate the deceased bone. This review focuses on approaches for tackling bone tuberculosis and various vertebrate deformities and treatments by medicinal use and by avoiding the surgical approaches.


Author(s):

Nigar Sultana Shaikh and Sujata P Sawarkar



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