Application of molecular imprinting technique for preparation of 5-flurouracil nanoparticles: testing antitumor activity in mice

Abstract

Recently, a considerable attention has been paid to nanotechnology. This study examined the potential chemotherapeutic effect of a molecularly

imprinted nanopreparation of 5-flfluorouracil against Ehrlich solid tumors grown in mice after transplanting tumor cells to female mice. Mice

were classified as; Group 1: control solid tumor bearing mice. Groups 2&3: tumor bearing mice treated with 5-flfluorouracil (5 and10 mg/kg, per

oral). Groups4&5: tumor bearing mice treated with nano-5-flfluorouracil (5 and10 mg/kg, per oral); all treatments continued for three weekly.

Treatment with nano-5-flfluorouracil produced greater antitumor effffect in comparison to free 5-flfluorouracil as designated by greater apoptosis

area in the dissected tumors and lower tumor mass. In addition, less count of mitotic fifigures and greater necrosis area were observed in the

tumor specimens with a decline in the number of proliferating nuclei in comparison to free 5-flfluorouracil. In addition, the findings revealed a

significant down-regulation of caspase-3 and vascular endothelial growth factor tumour expression. Together, these findings further affirm the

ability to use nanotechnology to increase 5-fluorouracil anticancer efficacy

Author(s):

Sawsan A. Zaitone

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