Structural Elucidation of Organic Natural Products By 1D, 2D and Multidimensional-NMR, Spectroscopy

Abstract

Nuclear magnetic resonance spectroscopy is the most important technique used in the process of structure elucidation of organic natural products.

NMR spectroscopy makes use of three approaches; those are one dimension (1D-NMR), two dimensions (2D-NMR) and three dimensions

(3D-NMR). The first approach of 1D-NMR.The 1H and13C, NMR spectra are the first tool used by chemists to perform the structure elucidation of

their products on a routine basis. Also, DEPT, 31P, 15N,19F, etc., generates good information about the structure of simple organic compounds,

but in case of larger molecules the 1D-NMR spectra are generally overcrowded. Hence, the second approach of 2D-NMR (COSY, HETCOR, HSQC,

HMBC, TOCSY, NOESY, etc.), used for large molecules like proteins. The Multidimensional-NMR, opening new windows for studying the protein

folding problem. The basis of the determination of the three-dimensional structure of biomolecules (proteins, DNA, RNA) , by providing the

resolution necessary to analyse their complex spectra. The aim of this study is to highlight of the recent advances in the application of NMR

techniques as structure elucidation tools to actual challenges in the field of organic natural products.This study is supported by interpretation of

structure of different organic compounds by different NMR techniques.

Author(s):

Sahar Awadallah Mohamed Hussein

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